Radiology 272 2 . Pp

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Yang, Hsin-Jung and Yumul, Roya and Tang, Richard and Cokic, Ivan and Klein, BloodVitals SPO2 Michael and Kali, Avinash and Blood Vitals Sobczyk, Olivia and Sharif, Behzad and Tang, Jun and Bi, Xiaoming and Tsaftaris, Sotirios A. and Li, Debiao and Conte, Antonio Hernandez and Fisher, Joseph A. and Dharmakumar, Rohan Assessment of myocardial reactivity to controlled hypercapnia with free-respiratory T2-ready cardiac blood oxygen stage-dependent MR imaging. Radiology, 272 (2). pp. Purpose: To examine whether controlled and tolerable ranges of hypercapnia could also be an alternate to adenosine, a routinely used coronary vasodilator, in healthy human topics and animals. Materials and Methods: Human studies had been authorised by the institutional evaluation board and had been HIPAA compliant. Eighteen subjects had end-tidal partial pressure of carbon dioxide (PetCO2) elevated by 10 mm Hg, and myocardial perfusion was monitored with myocardial blood oxygen stage-dependent (Bold) magnetic resonance (MR) imaging. Animal studies were accepted by the institutional animal care and use committee. 7) induced stenosis of the left anterior descending artery (LAD) underwent vasodilator challenges with hypercapnia and adenosine. LAD coronary blood movement velocity and free-breathing myocardial Bold MR responses were measured at every intervention. Appropriate statistical checks have been performed to guage measured quantitative changes in all parameters of interest in response to changes in partial strain of carbon dioxide. 75). In intact canines, there was a sigmoidal relationship between Bold MR response and PetCO2 with a lot of the response occurring over a ten mm Hg span. 99) responses have been similar to that of adenosine infusion. 12). Conclusion: Free-respiratory T2-ready myocardial Bold MR imaging confirmed that hypercapnia of 10 mm Hg could present a cardiac hyperemic stimulus just like adenosine.



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