Radiology 272 2 . Pp
Yang, Hsin-Jung and Yumul, Roya and Tang, Richard and Cokic, Ivan and Klein, Michael and Kali, Avinash and Sobczyk, Olivia and Sharif, monitor oxygen saturation Behzad and Tang, Jun and Bi, BloodVitals SPO2 device Xiaoming and Tsaftaris, Sotirios A. and Li, Debiao and Conte, Antonio Hernandez and Fisher, Joseph A. and Dharmakumar, Rohan Assessment of myocardial reactivity to controlled hypercapnia with free-respiration T2-prepared cardiac blood oxygen level-dependent MR imaging. Radiology, 272 (2). pp. Purpose: To examine whether controlled and tolerable ranges of hypercapnia may be another to adenosine, a routinely used coronary vasodilator, in wholesome human subjects and animals. Materials and Methods: Human research were authorised by the institutional evaluate board and had been HIPAA compliant. Eighteen subjects had finish-tidal partial stress of carbon dioxide (PetCO2) increased by 10 mm Hg, and myocardial perfusion was monitored with myocardial blood oxygen stage-dependent (Bold) magnetic resonance (MR) imaging. Animal studies had been accepted by the institutional animal care and use committee. 7) induced stenosis of the left anterior descending artery (LAD) underwent vasodilator challenges with hypercapnia and adenosine. LAD coronary blood circulate velocity and free-respiration myocardial Bold MR responses were measured at every intervention. Appropriate statistical checks had been performed to judge measured quantitative modifications in all parameters of interest in response to modifications in partial pressure of carbon dioxide. 75). In intact canines, there was a sigmoidal relationship between Bold MR response and PetCO2 with most of the response occurring over a 10 mm Hg span. 99) responses have been much like that of adenosine infusion. 12). Conclusion: Free-respiratory T2-ready myocardial Bold MR imaging confirmed that hypercapnia of 10 mm Hg could provide a cardiac hyperemic stimulus similar to adenosine.
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