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Eighteen subjects had finish-tidal partial stress of carbon dioxide (PetCO2) increased by 10 mm Hg, and myocardial perfusion was monitored with myocardial blood oxygen stage-dependent (Bold) magnetic resonance (MR) imaging. Animal studies had been accepted by the institutional animal care and use committee. 7) induced stenosis of the left anterior descending artery (LAD) underwent vasodilator challenges with hypercapnia and adenosine. LAD coronary blood circulate velocity and free-respiration myocardial Bold MR responses were measured at every intervention. Appropriate statistical checks had been performed to judge measured quantitative modifications in all parameters of interest in response to modifications in partial pressure of carbon dioxide. 75). In intact canines, there was a sigmoidal relationship between Bold MR response and PetCO2 with most of the response occurring over a 10 mm Hg span. 99) responses have been much like that of adenosine infusion. 12). 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